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Year Number of Results
1990 2
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2002 4
2003 17
2004 31
2005 31
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2007 63
2008 58
2009 90
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1,921 results

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Page 1
X-box binding protein 1 (XBP1) function in diseases.
Xu W, Wang C, Hua J. Xu W, et al. Cell Biol Int. 2021 Apr;45(4):731-739. doi: 10.1002/cbin.11533. Epub 2020 Dec 25. Cell Biol Int. 2021. PMID: 33325615 Review.
Here, the latest research progress of IRE1-XBP1 pathway in cancer, metabolic diseases, and other diseases was briefly introduced, and the relationship between several diseases and this pathway was analyzed. Besides, the new understanding and prospect of IRE1-XBP1 pa …
Here, the latest research progress of IRE1-XBP1 pathway in cancer, metabolic diseases, and other diseases was briefly introduced, and …
Nitrosative stress drives heart failure with preserved ejection fraction.
Schiattarella GG, Altamirano F, Tong D, French KM, Villalobos E, Kim SY, Luo X, Jiang N, May HI, Wang ZV, Hill TM, Mammen PPA, Huang J, Lee DI, Hahn VS, Sharma K, Kass DA, Lavandero S, Gillette TG, Hill JA. Schiattarella GG, et al. Nature. 2019 Apr;568(7752):351-356. doi: 10.1038/s41586-019-1100-z. Epub 2019 Apr 10. Nature. 2019. PMID: 30971818 Free PMC article.
Expression of one of the unfolded protein response effectors, the spliced form of X-box-binding protein 1 (XBP1s), was reduced in the myocardium of our rodent model and in humans with HFpEF. ...We report that iNOS-driven dysregulation of the IRE …
Expression of one of the unfolded protein response effectors, the spliced form of X-box-binding protein 1 …
X-box binding protein 1 as a key modulator in "healing endothelial cells", a novel EC phenotype promoting angiogenesis after MCAO.
Chen Z, Wang X, Wu H, Fan Y, Yan Z, Lu C, Ouyang H, Zhang S, Zhang M. Chen Z, et al. Cell Mol Biol Lett. 2022 Nov 8;27(1):97. doi: 10.1186/s11658-022-00399-5. Cell Mol Biol Lett. 2022. PMID: 36348288 Free PMC article.
Further analyses showed its high stemness to differentiate into other EC subtypes and potential to modulate inflammation and angiogenesis via excretion of signal molecules. We therefore identified X-box binding protein 1 (Xbp1) as a key m …
Further analyses showed its high stemness to differentiate into other EC subtypes and potential to modulate inflammation and angiogenesis vi …
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.
Liu Z, Wang M, Wang X, Bu Q, Wang Q, Su W, Li L, Zhou H, Lu L. Liu Z, et al. Redox Biol. 2022 Jun;52:102305. doi: 10.1016/j.redox.2022.102305. Epub 2022 Mar 28. Redox Biol. 2022. PMID: 35367811 Free PMC article.
While both TAA- and LPS-induced ALI triggered XBP1 activation in hepatocytes, hepatocyte-specific XBP1 knockout mice exhibited exacerbated ALI with increased hepatocellular pyroptosis and enhanced macrophage STING activation. ...Mitophagy restoration also inhibited …
While both TAA- and LPS-induced ALI triggered XBP1 activation in hepatocytes, hepatocyte-specific XBP1 knockout mice exhibited …
Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.
Welz L, Kakavand N, Hang X, Laue G, Ito G, Silva MG, Plattner C, Mishra N, Tengen F, Ogris C, Jesinghaus M, Wottawa F, Arnold P, Kaikkonen L, Stengel S, Tran F, Das S, Kaser A, Trajanoski Z, Blumberg R, Roecken C, Saur D, Tschurtschenthaler M, Schreiber S, Rosenstiel P, Aden K. Welz L, et al. Gastroenterology. 2022 Jan;162(1):223-237.e11. doi: 10.1053/j.gastro.2021.09.057. Epub 2021 Sep 30. Gastroenterology. 2022. PMID: 34599932 Free PMC article.
Together with genotoxic stressors and failing DNA repair, this self-renewal causes susceptibility toward malignant transformation. X-box binding protein 1 (XBP1) is a stress sensor involved in the unfolded protein response (UPR). ...The r …
Together with genotoxic stressors and failing DNA repair, this self-renewal causes susceptibility toward malignant transformation. X- …
Spliced X-box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR.
Wang X, Deng Y, Zhang G, Li C, Ding G, May HI, Tran DH, Luo X, Jiang DS, Li DL, Wei X, Xu L, Ferdous A, Gillette TG, Scherer PE, Jiang X, Wang ZV. Wang X, et al. Circulation. 2019 Aug 13;140(7):566-579. doi: 10.1161/CIRCULATIONAHA.118.038924. Epub 2019 Jun 10. Circulation. 2019. PMID: 31177839 Free PMC article.
METHODS: We used both gain- and loss-of-function approaches to genetically manipulate XBP1s (spliced X-box binding protein 1), the most conserved signaling branch of the unfolded protein response, in the heart. ...
METHODS: We used both gain- and loss-of-function approaches to genetically manipulate XBP1s (spliced X-box binding p …
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production.
Yang Z, Huo Y, Zhou S, Guo J, Ma X, Li T, Fan C, Wang L. Yang Z, et al. Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. doi: 10.1016/j.cmet.2022.10.010. Epub 2022 Nov 8. Cell Metab. 2022. PMID: 36351432 Free article.
Here, we demonstrate that, in cancer cells, the UPR component X-box binding protein 1 (XBP1) favors the synthesis and secretion of cholesterol, which activates myeloid-derived suppressor cells (MDSCs) and causes immunosuppression. ...Thus …
Here, we demonstrate that, in cancer cells, the UPR component X-box binding protein 1 (XBP1) favor …
Unspliced XBP1 Counteracts beta-Catenin to Inhibit Vascular Calcification.
Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z, Jia Y, Yu F, Zhao Y, Lin P, Ye C, Hu Y, Fu Y, Xu Q, Li Z, Kong W. Yang L, et al. Circ Res. 2022 Jan 21;130(2):213-229. doi: 10.1161/CIRCRESAHA.121.319745. Epub 2021 Dec 6. Circ Res. 2022. PMID: 34870453
BACKGROUND: Vascular calcification is a prevalent complication in chronic kidney disease and contributes to increased cardiovascular morbidity and mortality. XBP1 (X-box binding protein 1), existing as the XBP1u (unspliced XBP1) an …
BACKGROUND: Vascular calcification is a prevalent complication in chronic kidney disease and contributes to increased cardiovascular morbidi …
X-box binding protein 1 (XBP1): a potential role in chemotherapy response, clinical pathologic features, non-inflamed tumour microenvironment for breast cancer.
Zhu Z, Zhan H, Sun A, Huang H, Chen B, Zhang F. Zhu Z, et al. Biosci Rep. 2022 Jun 30;42(6):BSR20220225. doi: 10.1042/BSR20220225. Biosci Rep. 2022. PMID: 35543228 Free PMC article.
X-box binding protein 1 (XBP1) is mainly expressed in breast cancer (BC) in human cancers. ...Apart from BC, negative immunological correlations of XBP1 were not observed in other malignancies. XBP1 might shape the non-infla …
X-box binding protein 1 (XBP1) is mainly expressed in breast cancer (BC) in human cancers. ...Apar …
Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis.
Wang Q, Zhou H, Bu Q, Wei S, Li L, Zhou J, Zhou S, Su W, Liu M, Liu Z, Wang M, Lu L. Wang Q, et al. J Hepatol. 2022 Aug;77(2):312-325. doi: 10.1016/j.jhep.2022.02.031. Epub 2022 Mar 12. J Hepatol. 2022. PMID: 35292349 Free article.
BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is associated with the dysregulation of lipid metabolism and hepatic inflammation, though the underlying mechanisms remain unclear. We aimed to investigate the role of X-box binding protein- …
BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is associated with the dysregulation of lipid metabolism and hepatic inflammatio …
1,921 results